Developmental plasticity of CNS microglia
نویسندگان
چکیده
منابع مشابه
Developmental plasticity of CNS microglia.
Microglia arise from CD45(+) bone marrow precursors that colonize the fetal brain and play a key role in central nervous system inflammatory conditions. We report that parenchymal microglia are uncommitted myeloid progenitors of immature dendritic cells and macrophages by several criteria, including surface expression of "empty" class II MHC protein and their cysteine protease (cathepsin) profi...
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Developmental plasticity - the concept that adaptation to changing and unfavorable environmental conditions are possible but may come at the price of compromised health potentials - has evolutionary grounding as it facilitates survival but dissents with fundamental evolutionary principles in that it may advance the lesser fit. It is an important cornerstone of the Developmental Origins of Healt...
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Early life constraints affecting phenotype in later life is a trend consistently observed across different species. Of particular relevance to evolutionary medicine are the effects of intra-uterine growth leading to diabetes, hypertension, cardiovascular disease and other age-related disorders. The broader question of conditions under which such developmental plasticity or predictive adaptive r...
متن کاملDevelopmental plasticity
Early life experiences can have profound and persistent effects on traits expressed throughout the life course, with consequences for later life behavior, disease risk, and mortality rates. The shaping of later life traits by early life environments, known as 'developmental plasticity', has been well-documented in humans and non-human animals, and has consequently captured the attention of both...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.111152498